Intelligent Labs 5-MTHF Methylfolate 1mg – Quatrefolic® Activated Folate, 120 Capsules

Feeling run down or battling brain fog? Your folate intake might be the missing piece. Unlike synthetic folic acid, methylfolate (5-MTHF) is the active form of vitamin B9 your body can use straight away. Intelligent Labs brings you a pure, potent formula with Quatrefolic® – the most advanced form of methylfolate around.

Why Choose Quatrefolic®?

Quatrefolic is a fourth-generation folate developed by Gnosis. Its unique glucosamine binding, instead of calcium, makes it more soluble and absorbable. That means your body gets more of what it needs. Each capsule provides 1 mg of active 5-MTHF in a stable, Non-GM, gluten free, and vegan-friendly base. The glucosamine is sourced from non-shellfish origins, so it's suitable for vegetarians and those with allergies.

Health Benefits of Methylfolate

Folate, in its active methylfolate form, supports a range of normal body functions:

• Reduction of tiredness and fatigue – Folate contributes to normal energy-yielding metabolism.
• Normal homocysteine metabolism – Adequate folate helps maintain healthy homocysteine levels, supporting heart health.
• Normal psychological function – Folate plays a role in neurotransmitter synthesis, aiding mood and mental clarity.
• Normal immune system function – Proper folate levels support immune cell production.
• Maternal folate status – Increased folate intake before and during early pregnancy reduces the risk of neural tube defects. However, scientific evidence is not conclusive.

Always read the label and follow directions for use. This product is not intended to diagnose, treat, , or prevent any disease.

Who Should Consider This Supplement?

5-MTHF is especially helpful for:

• People with MTHFR gene variants – These genetic differences can hinder folic acid conversion. Methylfolate skips that step, giving you the active form directly.
• Women planning pregnancy or in early pregnancy – Adequate folate is vital for fetal neural tube development. This active form ensures optimal utilisation.
• Those seeking cardiovascular support – By supporting normal homocysteine metabolism, methylfolate contributes to heart health.
• Anyone experiencing fatigue or mood imbalances – Folate is involved in neurotransmitter and red blood cell production, so supplementation may boost energy and mood.

Recommended Dosage and Usage

Each capsule contains 1,000 mcg (1 mg) of active 5-MTHF. Take one capsule daily with food, or as directed by your healthcare professional. This 120-capsule bottle gives you a 4-month supply at one capsule per day. The upper limit for folate from supplements is 1,000 mcg daily for adults – this product provides that amount, so don't exceed one capsule per day unless under medical supervision. Consult your doctor before use, especially if pregnant, breastfeeding, or taking medication.

Folic Acid vs. Methylfolate: Which Is Better?

Synthetic folic acid is cheap and stable but needs conversion in the body – a two-step process that can be inefficient for those with MTHFR mutations. Methylfolate (5-MTHF) is the active, ready-to-use form. For people with MTHFR variants or who get side effects from folic acid, methylfolate is generally preferred. The Quatrefolic form here offers enhanced bioavailability and is gentle on the stomach.

Potential Side Effects and Precautions

Methylfolate is usually well tolerated. But high doses of any folate can mask a vitamin B12 deficiency, allowing neurological damage to progress unnoticed. If you're at risk for B12 deficiency (e.g., vegans, older adults, or those with pernicious anaemia), check with your healthcare provider first. Some people may experience mild digestive upset, sleep issues, or increased anxiety when starting. Starting with a lower dose or taking with food can help. If symptoms persist, stop and consult a professional.

Quality and Third-Party Testing

Intelligent Labs prioritises purity and potency. Each batch of this 5-MTHF supplement is independently third-party tested for identity, purity, and microbial contaminants. Certificates of analysis are available on request. Made in a GMP-certified facility, it's Non-GM, gluten free, and vegan-friendly.

Frequently Asked Questions

Can I take methylfolate with other B vitamins? Absolutely – it works synergistically with vitamin B12 and B6. Many take it as part of a methylated B-complex.

How long until I feel effects? Responses vary. Some notice better energy and mood within a few weeks; others need longer. Consistent daily use is key.

Is this safe during pregnancy? The 1,000 mcg daily dose falls within recommended pregnancy intake. But always consult your obstetrician before starting any supplement.