Life Extension High Potency Optimised Folate – L-Methylfolate – 8500 mcg DFE – 30 Tablets

Why Choose Active Folate?

Synthetic folic acid needs to be converted in the body to become active 5-MTHF, but many people have a common MTHFR gene variation that hampers this process. L-methylfolate bypasses that step entirely, making it a smarter choice for those wanting reliable, consistent folate support. This high-potency formula delivers 8,500 mcg DFE per tablet of the calcium salt of 5-MTHF, a stable and well-absorbed form.

What Is High Potency Optimised Folate?

Life Extension High Potency Optimised Folate supplies 8,500 mcg DFE of L-methylfolate (5-MTHF) – the bioactive form your body can use straight away. Unlike ordinary folic acid, no conversion is needed. This makes it ideal for individuals with MTHFR gene variants who may find it hard to process synthetic folic acid into active folate. Designed to support cardiovascular and cognitive health, it helps maintain normal homocysteine levels.

Who May Benefit From This Supplement?

This high-strength L-methylfolate supplement may be especially useful for:

• Adults focused on heart health who want to keep homocysteine levels in check.
• People with MTHFR gene variations needing a direct source of active folate.
• Women's planning pregnancy or during pregnancy – always consult your health care provider for the right dosage.
• Older adults who might have reduced absorption of synthetic folic acid.
• Vegetarians and vegans who could have lower dietary folate intake.

Recommended Dosage – How Much Folate Do You Need?

The recommended dietary intake (RDI) for folate is 400 mcg DFE for most adults, while pregnant women's are advised to consume 600 mcg DFE daily. However, some individuals may benefit from higher doses under professional guidance. Each tablet provides 8,500 mcg DFE (850 mcg folic acid equivalents) – well above the RDI. The tolerable upper intake level (UL) for folate from supplements is 1,000 mcg. Always speak with a healthcare professional before taking high-dose supplements, particularly if you are pregnant or have underlying health conditions.

Health Benefits of L-Methylfolate

Folate is a water-soluble B vitamin essential for DNA synthesis, cell division, and red blood cell formation. The active form, L-methylfolate, offers targeted support:

• Heart health: Folate helps maintain normal homocysteine levels. Elevated homocysteine is a marker for cardiovascular health, and keeping it within a normal range supports overall heart function.
• Cognitive function: Homocysteine has also been linked with normal cognitive decline. By supporting healthy homocysteine metabolism, L-methylfolate may help preserve cognitive health as you age.
• Red blood cell formation: Folate contributes to normal blood cell production, crucial for oxygen transport and energy.
• Pregnancy support: Adequate folate intake during pregnancy can reduce the risk of neural tube defects. The evidence supports this benefit.

This product is not intended to diagnose, treat, or prevent any disease. Always read the labelled and follow directions for use.

How to Choose a Quality Folate Supplement

When selecting a folate supplement, consider these points:

• Form: L-methylfolate (5-MTHF) is best for bioavailability, especially for those with MTHFR variations.
• Purity: Look for non-genetically modified, Gluten Free, and vegetarian formulations. Life Extension meets these standards.
• Third-party testing: Certificates of Analysis confirm potency and purity.
• Dosage: Choose a dose that matches your needs – high potency for targeted support, lower for maintenance.

This product ticks all the boxes, manufactured with rigorous quality control.

Potential Side Effects and Precautions

Folate is generally safe, but high doses may cause minor side effects like nausea, bloating, or sleep disturbances. Very high intake can mask vitamin B12 deficiency, especially in older adults – so B12 status should be monitored. Do not exceed recommended doses without medical advice. If you are pregnant, nursing, or on medication, consult your health care provider before use.

Frequently Asked Questions

Can I take this with other B vitamins?

Yes, folate works well with vitamin B12 and vitamin B6. Many users take it as part of a B-complex or with a high-quality multivitamin.

How should I store these tablets?

Store in a cool, dry place away from direct sunlight. Keep the bottle tightly sealed to maintain potency.

Is this product suitable for vegans?

Yes, this supplement is vegetarian and suitable for vegans. The tablets contain no animal-derived ingredients.

How long does one bottle last?

One bottle contains 30 tablets. Take one tablet per day, so it provides a 30-day supply.