High Potency Optimised Folate 5000 mcg, 30 Vegetarian Tablets (Pack of 2)

Who Should Consider This Supplement?

If you've got MTHFR gene variants that make it hard to convert folic acid, or if you're after a high-potency folate to support homocysteine levels, Optimised Folate from Life Extension might be just what you need. This formula delivers 5,000 mcg of L-methylfolate (5-MTHF) per tablet — the active form your body can use straight away. It's also popular with those planning pregnancy, older adults, or anyone with absorption concerns. But because of its strength, it's best to chat with your healthcare professional before starting, especially if you're pregnant, breastfeeding, or on medications that affect folate metabolism.

What Is Optimised Folate?

Optimised Folate provides 5,000 mcg of L-methylfolate (5-MTHF), the biologically active form of folate. Unlike synthetic folic acid, L-methylfolate doesn't require enzymatic conversion, so your body can use it immediately. That makes it a top pick for people with MTHFR gene variations that impair folate metabolism. Each bottle has 30 vegetarian tablets, and this pack comes with two bottles — a handy two-month supply.

Health Benefits of L-Methylfolate

Folate is a water-soluble B vitamin essential for many body functions. As the active form, L-methylfolate directly supports:

• Homocysteine metabolism: Helps maintain normal homocysteine levels, which is important for cardiovascular and neurological health.
• Red blood cell formation: Contributes to normal red blood cell production, helping reduce tiredness and fatigue.
• DNA synthesis and repair: Critical for cell division and growth.
• Neurotransmitter production: Supports the synthesis of serotonin, dopamine, and norepinephrine, influencing mood and cognition.

These structure-function benefits are backed by extensive research on folate's roles in the body. Always read the label and follow directions for use.

Folic Acid vs. Methylfolate: Which Is Better?

Most multivitamins contain folic acid, a synthetic form that your liver must convert into L-methylfolate. But up to 60% of people have genetic variations (MTHFR) that reduce this conversion efficiency. That's where Optimised Folate shines — it gives you the active form straight up, so everyone gets the full benefit. Even for those without MTHFR mutations, methylfolate may be more bioavailable and less likely to mask vitamin B12 deficiency at high doses.

Recommended Dosage

The standard serve is one tablet daily, providing 5,000 mcg of L-methylfolate. This is well above the usual 400 mcg RDI for adults and the 400–800 mcg recommended during pregnancy. The tolerable upper intake level for synthetic folic acid is 1,000 mcg, but that limit doesn't apply to L-methylfolate. Still, high doses should only be used under supervision of a healthcare professional, especially if you have a medical condition or take medications that interact with folate metabolism.

How to Choose a Quality Folate Supplement

When picking a folate product, look at the form (methylfolate vs. folic acid), dosage, and third-party testing. Life Extension is a trusted brand that follows Good Manufacturing Practices (GMP). This product is vegetarian, Non-GM, and free of common allergens like gluten, soy, and dairy. Always read the label and follow directions for use.

Potential Side Effects and Precautions

High-dose L-methylfolate is generally well tolerated, but some people might experience mild flushing, nausea, or anxiety. More importantly, very high doses can mask a vitamin B12 deficiency, potentially allowing neurological damage to go unnoticed. If you're B12 deficient or have pernicious anaemia, correct B12 levels before starting high-dose folate. Consult your healthcare professional before use, especially if you're taking seizure medications, methotrexate, or other drugs that interact with folate metabolism. Always read the label and follow directions for use.

Frequently Asked Questions

Can I take this if I have the MTHFR mutation? Yes, this product is specifically formulated for individuals with MTHFR variants who cannot efficiently convert folic acid.

Is this safe during pregnancy? The 5,000 mcg dose exceeds typical prenatal recommendations. Consult your doctor before using during pregnancy or while breastfeeding.

Do I need to take it with food? L-methylfolate can be taken with or without food. Taking it with meals may reduce any potential digestive upset.

How does this compare to taking folic acid? This product provides the active form, which is more readily used by the body, especially for those with genetic conversion issues.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, , or prevent any disease. Always read the label and follow directions for use.