Natural Factors BioCoenzymated Methylfolate 1000 mcg, 60 Tablets

Key Benefits of Methylfolate and B12

Cardiovascular Support: Methylfolate and methylcobalamin work together to metabolise homocysteine, an amino acid linked to heart health when levels are balanced.*
Neurological Health: Both nutrients play essential roles in neurotransmitter synthesis and myelin sheath maintenance, supporting cognitive function and mood.*
Red Blood Cell Formation: Folate and B12 are required for erythropoiesis, helping maintain healthy oxygen transport.*
Immune Function: Proper methylation supports immune cell production and activity.*
These benefits are grounded in the biochemical roles of methylfolate and methylcobalamin as cofactors in methylation reactions.

What Makes BioCoenzymated Methylfolate Special?

Natural Factors uses the patented Quatrefolic® methylfolate, a highly stable and bioavailable form. The addition of methylcobalamin (the active B12) ensures synergistic action for methylation. This product is Non-GM, gluten free, and vegetarian, with no artificial preservatives, colors, or sweeteners. It is manufactured in a GMP-certified facility owned by Natural Factors, ensuring quality control from raw material to finished product.

Who Should Consider a Methylfolate Supplement?

Anyone with the MTHFR gene mutation may benefit from methylfolate, as their bodies cannot efficiently convert folic acid. Additionally, individuals with elevated homocysteine levels, those following a vegan or vegetarian diet (since folate is abundant in leafy greens but B12 is not), and older adults with reduced absorption may find this supplement valuable. It is also suitable for those seeking to support cardiovascular and neurological health through proper methylation.*

How to Use This Supplement for Best Results

Chew or dissolve one tablet daily in the mouth before swallowing, or as directed by a health professional. The sublingual route enhances absorption of methylcobalamin. For optimal methylation support, take consistently with meals. Do not exceed recommended dose unless advised by a healthcare provider. Always read the label and follow directions for use.

Frequently Asked Questions

Can I take this if I have the MTHFR mutation?

Yes, this supplement provides the active form of folate that bypasses the MTHFR conversion step, making it ideal for those with genetic variations.

Is it safe to take 1000 mcg of methylfolate daily?

The Tolerable Upper Intake Level for folate is 1000 mcg from supplements; this product meets that threshold. Higher doses should only be used under medical supervision.

Does this contain folic acid?

No, it contains methylfolate (Quatrefolic®) and methylcobalamin—both are active forms, not synthetic folic acid or cyanocobalamin.

What Is Methylfolate and Why Is It Important?

Methylfolate, also known as 5-methyltetrahydrofolate (5-MTHF), is the biologically active form of folate. Unlike folic acid, which requires enzymatic conversion in the body, methylfolate is ready for immediate use. This is critical for individuals with genetic variations like MTHFR, which impair the conversion of folic acid to its active form. Natural Factors BioCoenzymated Methylfolate delivers 1,000 mcg of this essential nutrient, paired with methylcobalamin vitamin B12, to support methylation—a biochemical process vital for DNA synthesis, cleansing, and cellular energy.*

• Supports cardiovascular, immune, and neurological health*
• Active methylated forms: methylfolate (1,000 mcg) and methylcobalamin B12
• Ideal for MTHFR genetic variations
• Non-GM, gluten free, vegetarian
• No artificial preservatives, colors, or sweeteners
• Chewable or dissolvable tablet for enhanced absorption

Usage: Chew or dissolve 1 tablet daily in the mouth before swallowing or as directed by a health professional. Store in a cool, dry place.

Disclaimer: Always read the label and follow directions for use. Supplementation should not replace a balanced diet.