THORNE Methyl-Guard - Healthy Methylation Support - 180 Capsules

Who Needs Methylation Support?

If you carry MTHFR gene variations, your body struggles to use synthetic folic acid – that’s where Methyl-Guard steps in. It supplies pre-methylated folate (5-MTHF) and active B12 (methylcobalamin) so your system can get straight to work. Vegans and vegetarians often lack dietary B12, making this a smart choice. Older adults, athletes, and anyone under physical stress may also find extra methylation support beneficial. THORNE is trusted by over 100 professional sports teams and is the #1 most recommended clinical brand amongst consumers and health care practitioners (2026 independent survey), so you’re in good company.*

Key Benefits for Heart, Brain, and Bone Health

Proper methylation keeps your blood vessels flexible and supports cardiovascular function. By helping metabolise homocysteine, Methyl-Guard promotes arterial health and heart well-being.* For your brain, active B vitamins enhance nerve cell communication and cognitive performance. Methylation also influences bone metabolism, contributing to bone density and strength.* Each serving delivers 2 mg of 5-MTHF (as calcium folinate), 1 mg of methylcobalamin, 20 mg of vitamin B6 (as P-5-P), and 500 mg of betaine anhydrous – a comprehensive dose to back these vital processes.*

What Makes THORNE Methyl-Guard Different?

Not all B vitamin supplements are equal. Many use synthetic folic acid and cyanocobalamin, which need extra conversion steps and may not work for everyone. Methyl-Guard uses only active, methylated forms: 5-MTHF (calcium folinate) – the natural form – and methylcobalamin, the coenzyme B12. Betaine acts as a direct methyl donor, while vitamin B6 comes as P-5-P, the active coenzyme. The formula is free from gluten, dairy, and soy, and is made in a cGMP-compliant facility with third-party testing for purity and potency.

How to Choose a Methylation Supplement

When shopping for a methylation product, look for these five things: First, folate and B12 must be in active forms (5-MTHF and methylcobalamin). Second, additional methyl donors like betaine or SAMe are a plus. Third, vitamin B6 should be P-5-P. Fourth, pick a product without unnecessary additives or allergens. Fifth, choose a reputable brand with transparent quality practices. THORNE ticks all these boxes, offering a potent, well-absorbed formula in easy-to-swallow capsules.

What Is Methyl-Guard and Why Does Methylation Matter?

Methylation is a fundamental biochemical process happening in every cell of your body. It drives DNA synthesis, gene expression, neurotransmitter production, detoxification, and homocysteine regulation. When methylation pathways are compromised, it can affect your heart, brain, and bones. THORNE Methyl-Guard is a targeted supplement designed to optimise methylation by providing the most bioavailable forms of key nutrients: active folate (5-MTHF), active vitamin B12 (methylcobalamin), vitamin B6 (as pyridoxal 5'-phosphate), and betaine (trimethylglycine). These ingredients work together to support healthy methylation and maintain homocysteine levels already within a normal range.*

Frequently Asked Questions

How should I take Methyl-Guard?

The recommended dose is 2 capsules daily with food. One bottle of 180 capsules gives you a 90-day supply. For best absorption, take with a meal containing some fat.

Can I take it with other supplements?

Yes, it pairs well with other Thorne products. But if you’re on medications (especially blood thinners) or have a medical condition, talk to your health care practitioner first.

Is it suitable for vegans?

Yes. The capsules are made from hypromellose (vegetable cellulose) and the formula contains no animal-derived ingredients.

Does it contain folic acid?

No. It contains calcium folinate (5-MTHF), the active form of folate, making it ideal for those with MTHFR gene variations.

Always read the label and follow the directions for use. This product is not intended to diagnose, treat, or prevent any disease.